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This volume edited by Tabea Ihsane focuses on different aspects of the distribution, semantics, and internal structure of nominal constituents with a “partitive article” in its indefinite interpretation and of potentially corresponding bare nouns. It further deals with diachronic issues, such as grammaticalization and evolution in the use of “partitive articles”. The outcome is a snapshot of current research into “partitive articles” and the way they relate to bare nouns, in a cross-linguistic perspective and on new data: the research covers noteworthy data (fieldwork data and corpora) from Standard languages - like French and Italian, but also German - to dialectal and regional varieties, including endangered ones like Francoprovençal.
The definitive history of the state of Michigan, from its early settlement by Native Americans to the end of the 19th century. Written by historian Charles Moore, this book covers all the major events and figures in Michigan's history, including the French explorers, the British occupation, the American Revolution, and the Civil War. With a wealth of archival material and personal anecdotes, this book is an engaging and informative read for anyone interested in Michigan history. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
"Sergei Eisenstein (1898-1948), creator of such masterpieces as Battleship Potemkin, Alexander Nevsky and Ivan the Terrible, was perhaps the greatest of all film directors. He wrote his autobiography in 1946, two years before his death, and it is a work of major importance in the light it sheds on his personality and mercurial genius. Vivid, eccentric and free-ranging, Immoral Memories is written in a style reminiscent of the brilliant visual effects of montage and dynamic progression that characterize its author's film-making technique. He recounts his life in Russia from the time of the Revolution, during which he served in the Bolshevik army as a volunteer, his travels in the West and his...